Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes.

@article{Jiang1995MolecularCA,
  title={Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes.},
  author={Qing Yan Jiang and Jeffrey M. Voigt and Howard D. Colby},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={209 3},
  pages={
          1149-56
        }
}
Studies were done to characterize a guinea pig adrenal microsomal P450 that had been linked with xenobiotic metabolism in the inner zone of the gland. N-terminal amino acid sequencing of the isolated protein revealed homology with members of the CYP2D subfamily. A human CYPD2D6 cDNA probe was used to screen a guinea pig adrenal cDNA library and a full-length clone was obtained having an open reading frame encoding a 500 amino acid protein. The sequence was found to be highly homologous with all… CONTINUE READING
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