Molecular cloning and nucleotide sequence of human glucocerebrosidase cDNA.

  title={Molecular cloning and nucleotide sequence of human glucocerebrosidase cDNA.},
  author={J{\"u}rgen Sorge and Carol Taylor West and Beryl Westwood and Ernest Beutler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={82 21},
Mutations in the human glucocerebrosidase gene cause Gaucher disease. A cDNA clone containing the entire human glucocerebrosidase coding region from normal cells has been isolated using lambda gt11 expression libraries. The complete nucleotide sequence, a restriction map, and a hydropathy profile are presented. Hybridization to chromosome-specific DNA localizes the human glucocerebrosidase gene to chromosome 1. The likely precursor protein is 515 amino acids long. The NH2-terminal 19 amino… CONTINUE READING
41 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 41 extracted citations

Similar Papers

Loading similar papers…