Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor.

@article{GonzlezEspinosa2001MolecularCA,
  title={Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor.},
  author={Claudia Gonz{\'a}lez-Espinosa and Mar{\'i}a Teresa Romero-{\'A}vila and D M Mora-Rodr{\'i}guez and Diana Gonz{\'a}lez-Espinosa and Jes{\'u}s Adolfo Garc{\'i}a-S{\'a}inz},
  journal={European journal of pharmacology},
  year={2001},
  volume={426 3},
  pages={147-55}
}
In the present paper, the cloning and expression of the guinea pig alpha(1A)-adrenoceptor is presented. The nucleotide sequence had an open reading frame of 1401 bp that encoded a 466 amino-acid protein with an estimated molecular mass of approximately 51.5 kDa. When the clone was expressed in Cos-1 cells, specific high-affinity binding of [(3)H]prazosin… CONTINUE READING