Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.

@article{Race1999MolecularCA,
  title={Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.},
  author={J. E. Race and Fadi N Makhlouf and P. Logue and F. H. Wilson and P. Dunham and E. J. Holtzman},
  journal={American journal of physiology. Cell physiology},
  year={1999},
  volume={277 6},
  pages={C1210-C1219}
}
We isolated and characterized a novel K-Cl cotransporter, KCC3, from human placenta. The deduced protein contains 1,150 amino acids. KCC3 shares 75-76% identity at the amino acid level with human, pig, rat, and rabbit KCC1 and 67% identity with rat KCC2. KCC3 is 40 and 33% identical to two Caenorhabditis elegans K-Cl cotransporters and ∼20% identical to other members of the cation-chloride cotransporter family (CCC), two Na-K-Cl cotransporters (NKCC1, NKCC2), and the Na-Cl cotransporter (NCC… Expand
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