Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI).

@article{Xie2010MolecularCA,
  title={Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI).},
  author={Lilan Xie and Liurong Fang and Dang Wang and Rui Luo and Kaimei Cai and Huanchun Chen and Shaobo Xiao},
  journal={Developmental and comparative immunology},
  year={2010},
  volume={34 3},
  pages={293-9}
}
The DNA-dependent activator of IFN-regulatory factors (DAI) is a recently identified DNA sensor for intracellular DNA that triggers a signal for the production of type I IFN. Here we report the cloning and characterization of porcine DAI (poDAI). The full-length of poDAI encodes 439 amino acids, contains two N-terminal DNA-binding domains and shows similarity to mouse, rat, dog, monkey, human, horse and cattle counterparts ranging from 44% to 67%. poDAI mRNA expression was mainly detected in… CONTINUE READING

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