Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis.

@article{Larbat2007MolecularCA,
  title={Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis.},
  author={Romain Larbat and Sandra Kellner and Silvia Specker and Alain Hehn and Eric Gontier and Joachim Hans and Fr{\'e}d{\'e}ric Bourgaud and Ulrich Matern},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 1},
  pages={542-54}
}
Ammi majus L. accumulates linear furanocoumarins by cytochrome P450 (CYP)-dependent conversion of 6-prenylumbelliferone via (+)-marmesin to psoralen. Relevant activities, i.e. psoralen synthase, are induced rapidly from negligible background levels upon elicitation of A. majus cultures with transient maxima at 9-10 h and were recovered in labile microsomes. Expressed sequence tags were cloned from elicited Ammi cells by a nested DD-RT-PCR strategy with CYP-specific primers, and full-size cDNAs… CONTINUE READING

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Ammi majus L. accumulates linear furanocoumarins by cytochrome P450 ( CYP)-dependent conversion of 6-prenylumbelliferone via ( + ) -marmesin to psoralen .
Related plants , i.e. Heracleum mantegazzianum , are known to produce both linear and angular furanocoumarins by analogous conversion of 8-prenylumbelliferone via ( + ) -columbianetin to angelicin , and it was suggested that angelicin synthase has evolved from psoralen synthase .
Molecular cloning and functional characterization of psoralen synthase , the first committed monooxygenase of furanocoumarin biosynthesis .
Ammi majus L. accumulates linear furanocoumarins by cytochrome P450 ( CYP)-dependent conversion of 6-prenylumbelliferone via ( + ) -marmesin to psoralen .
Related plants , i.e. Heracleum mantegazzianum , are known to produce both linear and angular furanocoumarins by analogous conversion of 8-prenylumbelliferone via ( + ) -columbianetin to angelicin , and it was suggested that angelicin synthase has evolved from psoralen synthase .
Molecular cloning and functional characterization of psoralen synthase , the first committed monooxygenase of furanocoumarin biosynthesis .
Related plants , i.e. Heracleum mantegazzianum , are known to produce both linear and angular furanocoumarins by analogous conversion of 8-prenylumbelliferone via ( + ) -columbianetin to angelicin , and it was suggested that angelicin synthase has evolved from psoralen synthase .
Ammi majus L. accumulates linear furanocoumarins by cytochrome P450 ( CYP)-dependent conversion of 6-prenylumbelliferone via ( + ) -marmesin to psoralen .
Molecular cloning and functional characterization of psoralen synthase , the first committed monooxygenase of furanocoumarin biosynthesis .
Related plants , i.e. Heracleum mantegazzianum , are known to produce both linear and angular furanocoumarins by analogous conversion of 8-prenylumbelliferone via ( + ) -columbianetin to angelicin , and it was suggested that angelicin synthase has evolved from psoralen synthase .
Ammi majus L. accumulates linear furanocoumarins by cytochrome P450 ( CYP)-dependent conversion of 6-prenylumbelliferone via ( + ) -marmesin to psoralen .
Molecular cloning and functional characterization of psoralen synthase , the first committed monooxygenase of furanocoumarin biosynthesis .
Related plants , i.e. Heracleum mantegazzianum , are known to produce both linear and angular furanocoumarins by analogous conversion of 8-prenylumbelliferone via ( + ) -columbianetin to angelicin , and it was suggested that angelicin synthase has evolved from psoralen synthase .
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