Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway

@article{Ginis2011MolecularCA,
  title={Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway},
  author={Olivia Ginis and Vincent Courdavault and C{\'e}line M{\'e}lin and Arnaud Lanoue and Nathalie Giglioli-Guivarc’h and Benoit St-Pierre and Martine Courtois and Audrey Oudin},
  journal={Molecular Biology Reports},
  year={2011},
  volume={39},
  pages={5433-5447}
}
The Madagascar periwinkle produces monoterpenoid indole alkaloids (MIA) of high interest due to their therapeutical values. The terpenoid moiety of MIA is derived from the methyl erythritol phosphate (MEP) and seco-iridoid pathways. These pathways are regarded as the limiting branch for MIA biosynthesis in C. roseus cell and tissue cultures. In previous studies, we demonstrated a coordinated regulation at the transcriptional and spatial levels of genes from both pathways. We report here on the… CONTINUE READING

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