Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

@article{Eckner1994MolecularCA,
  title={Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.},
  author={R. Eckner and M. Ewen and D. Newsome and M. Gerdes and J. Decaprio and J. Lawrence and D. Livingston},
  journal={Genes & development},
  year={1994},
  volume={8 8},
  pages={
          869-84
        }
}
The growth-controlling functions of the adenovirus E1A oncoprotein depend on its ability ot interact with a set of cellular proteins. Among these are the retinoblastoma protein, p107, p130, and p300. We have isolated a cDNA encoding full-length human p300 and mapped the chromosomal location of the gene to chromosome 22q13. p300 contains three cysteine- and histidine-rich regions of which the most carboxy-terminal region interacts specifically with E1A. In its center, p300 contains a bromodomain… Expand
1,036 Citations
Regulation of the Human Proliferating Cell Nuclear Antigen Promoter by the Adenovirus E1A-Associated Protein p107
  • 22
  • PDF
The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.
  • 41
  • PDF
Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP
  • 50
  • PDF
The N-Terminal Domain of p73 Interacts with the CH1 Domain of p300/CREB Binding Protein and Mediates Transcriptional Activation and Apoptosis
  • 89
  • PDF
E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity.
  • 61
  • Highly Influenced
  • PDF
...
1
2
3
4
5
...