Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

@article{Eckner1994MolecularCA,
  title={Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.},
  author={Richard Eckner and Mark E. Ewen and David L. Newsome and Maria Gerdes and James A. DeCaprio and J B Lawrence and David Livingston},
  journal={Genes & development},
  year={1994},
  volume={8 8},
  pages={
          869-84
        }
}
The growth-controlling functions of the adenovirus E1A oncoprotein depend on its ability ot interact with a set of cellular proteins. Among these are the retinoblastoma protein, p107, p130, and p300. We have isolated a cDNA encoding full-length human p300 and mapped the chromosomal location of the gene to chromosome 22q13. p300 contains three cysteine- and histidine-rich regions of which the most carboxy-terminal region interacts specifically with E1A. In its center, p300 contains a bromodomain… CONTINUE READING

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