Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.

@article{Yokoyama1994MolecularCA,
  title={Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.},
  author={K Yokoyama and Hirokazu Suzuki and Ken ichi Yasumoto and Yasushi Tomita and Shigeki Shibahara},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1217 3},
  pages={317-21}
}
We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells established that TRP-2 is DOPAchrome tautomerase. Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart. 

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