Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.

@article{Gough1988MolecularCA,
  title={Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.},
  author={N. M. Gough and David P. Gearing and Jonathan Alan King and Tracy A Willson and Douglas J. Hilton and Nicos A. Nicola and Donald Metcalf},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 8},
  pages={2623-7}
}
A human homologue of the recently cloned murine leukemia-inhibitory factor (LIF) gene was isolated from a genomic library by using the murine cDNA as a hybridization probe. The nucleotide sequence of the human gene indicated that human LIF has 78% amino acid sequence identity with murine LIF, with no insertions or deletions, and that the region of the human gene encoding the mature protein has one intervening sequence. After oligonucleotide-mediated mutagenesis, the mature protein-coding region… CONTINUE READING
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