Molecular cloning and expression of the gene for a human D1 dopamine receptor

@article{Dearry1990MolecularCA,
  title={Molecular cloning and expression of the gene for a human D1 dopamine receptor},
  author={A. Dearry and J. Gingrich and P. Falardeau and R. Fremeau and M. Bates and M. Caron},
  journal={Nature},
  year={1990},
  volume={347},
  pages={72-76}
}
THE diverse physiological actions of dopamine are mediated by its interaction with two basic types of G protein-coupled receptor, D1 and D2, which stimulate and inhibit, respectively, the enzyme adenylyl cyclase1. Alterations in the number or activity of these receptors may be a contributory factor in diseases such as Parkinson's disease and schizophrenia. Here we describe the isolation and characterization of the gene encoding a human D1 dopamine receptor. The coding region of this gene is… Expand
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  • D. Grandy, Y. Zhang, +7 authors O. Civelli
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
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