Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.

@article{Freije1994MolecularCA,
  title={Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.},
  author={Jos{\'e} M P Freije and Irene D{\'i}ez-Itza and Milagros Balb{\'i}n and Luis M. S{\'a}nchez and Rafael Blasco and Jorge Tolivia and Carlos L{\'o}pez-Ot{\'i}n},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 24},
  pages={16766-73}
}
A cDNA coding for a new human matrix metalloproteinase (MMP) has been cloned from a cDNA library derived from a breast tumor. The isolated cDNA contains an open reading frame coding for a polypeptide of 471 amino acids. The predicted protein sequence displays extensive similarity to the previously known MMPs and presents all the structural features characteristic of the members of this protein family, including the well conserved PRCGXPD motif, involved in the latency of the enzyme and the zinc… CONTINUE READING

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