Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.

@article{Harteneck1991MolecularCA,
  title={Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.},
  author={Christian Harteneck and Barbara Wedel and Doris Koesling and J{\"u}rgen Malkewitz and Eycke B{\"o}hme and Guenter Schultz},
  journal={FEBS letters},
  year={1991},
  volume={292 1-2},
  pages={
          217-22
        }
}
A cDNA coding for a new subunit of soluble guanylyl cyclase with a calculated molecular mass of 81.7 kDa was cloned and sequenced. On the basis of sequence homology, the new subunit appears to be an isoform of the alpha 1-subunit and was designated alpha 2 as the new subunit is very similar to the alpha 1-subunit in the middle and C-terminal part; it is quite diverse in the N-terminal part. Preceding experiments had shown that coexpression of the alpha 1- and beta 1-subunits is necessary to… CONTINUE READING

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