Molecular cloning and expression of a human chondroitin synthase.

  title={Molecular cloning and expression of a human chondroitin synthase.},
  author={Hiroshi Kitagawa and Toru Uyama and Kazuyuki Sugahara},
  journal={The Journal of biological chemistry},
  volume={276 42},
We have identified a human chondroitin synthase from the HUGE (human unidentified gene-encoded large proteins) protein data base by screening with two keywords: "one transmembrane domain" and "galactosyltransferase family." The identified protein consists of 802 amino acids with a type II transmembrane protein topology. The protein showed weak homology to the beta1,3-galactosyltransferase family on the amino-terminal side and to the beta1,4-galactosyltransferase family on the carboxyl-terminal… CONTINUE READING
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