Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

@article{Sessa1992MolecularCA,
  title={Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.},
  author={William C Sessa and Jeffrey K. Harrison and Cynthia M. Barber and D W Zeng and Marcel E. Durieux and Diane D'Angelo and Kevin R Lynch and Michael J G Peach},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 22},
  pages={15274-6}
}
Endothelium-derived relaxing factor (EDRF), identified as nitric oxide (NO), is derived from a guanidino nitrogen of L-arginine via its metabolism by nitric oxide synthase (NOS). Herein, we report the molecular cloning of a cDNA encoding the constitutive calcium-calmodulin (Ca2+/CaM)-regulated nitric oxide synthase (ECNOS). A full-length ECNOS clone was isolated by screening a bovine aortic endothelial cell cDNA library using a fragment of rat brain NOS (bNOS) cDNA. This cDNA has an open… CONTINUE READING

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