Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).

@article{Race1999MolecularCA,
  title={Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).},
  author={Joanne E Race and Steven M Grassl and William Jones Williams and Eli J Holtzman},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={255 2},
  pages={508-14}
}
The cloned organic anion transporters from rat, mouse, and winter flounder (rOAT1, mOAT1, fROAT) mediate the coupled exchange of alpha-ketoglutarate with multiple organic anions, including p-aminohippurate (PAH). We have isolated two novel gene products from human kidney which bear significant homology to the known OATs and belong to the amphiphilic solute facilitator (ASF) family. The cDNAs, hOAT1 and hOAT3, encode for 550- and 568-amino-acid residue proteins, respectively. hOAT1 and hOAT3… CONTINUE READING