Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis.

@article{Kakar1999MolecularCA,
  title={Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis.},
  author={Sham S. Kakar and Lothar H Jennes},
  journal={Cytogenetics and cell genetics},
  year={1999},
  volume={84 3-4},
  pages={211-6}
}
We cloned and sequenced the cDNA of a potent tumor transforming gene (TUTR1) from human testis and determined its primary structure. The TUTR1 cDNA is composed of 656 nucleotides and encodes a novel protein of 202 amino acids. The predicted TUTR1 protein is extremely hydrophilic and contains two proline-rich motifs at its C-terminus. Northern blot analysis of the mRNA from various human tissues and tumors revealed that TUTR1 mRNA is highly expressed in tumors of the pituitary gland, adrenal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Similar Papers

Loading similar papers…