Molecular cloning and characterization of the human A3 adenosine receptor.

  title={Molecular cloning and characterization of the human A3 adenosine receptor.},
  author={Christopher A. Salvatore and Marlene A. Jacobson and H E Taylor and Judy Linden and Rodger G. Johnson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 21},
The human A3 adenosine receptor was cloned from a striatal cDNA library using a probe derived from the homologous rat sequence. The cDNA encodes a protein of 318 amino acids and exhibits 72% and 85% overall identity with the rat and sheep A3 adenosine receptor sequences, respectively. Specific and saturable binding of the adenosine receptor agonist N6-(4-amino-3-[125I]iodobenzyl)adenosine [125I]ABA was measured on the human A3 receptor stably expressed in Chinese hamster ovary cells with a Kd… CONTINUE READING
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