Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.

@article{Lau1999MolecularCA,
  title={Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.},
  author={K F Lau and Christopher J Miller and Brian H. Anderton and Pang-Chui Shaw},
  journal={Genomics},
  year={1999},
  volume={60 2},
  pages={121-8}
}
Glycogen synthase kinase 3beta (GSK-3beta) is a proline-directed kinase that forms part of the wingless signaling pathway. Recent studies have shown that GSK-3beta phosphorylates the microtubule-associated protein tau in vitro and in cell culture. Tau is the principal component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease, and PHF-tau is hyperphosphorylated. GSK-3beta is therefore one of the candidate kinases for phosphorylating tau in Alzheimer… CONTINUE READING
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