Molecular cloning and characterization of the human beta-like globin gene cluster.

@article{Fritsch1980MolecularCA,
  title={Molecular cloning and characterization of the human beta-like globin gene cluster.},
  author={Edward F. Fritsch and Richard M. Lawn and Tom Maniatis},
  journal={Cell},
  year={1980},
  volume={19 4},
  pages={959-72}
}
The genes encoding human embryonic (epsilon), fetal (G gamma, A gamma) and adult (delta, beta) beta-like globin polypeptides were isolated as a set of overlapping cloned DNA fragments from bacteriophage lambda libraries of high molecular weight (15-20 kb) chromosomal DNA. The 65 kb of DNA represented in these overlapping clones contains the genes for all five beta-like polypeptides, including the embryonic epsilon-globin gene, for which the chromosomal location was previously unknown. All five… CONTINUE READING

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