Molecular cloning and characterization of the gene encoding human NeuroD

  title={Molecular cloning and characterization of the gene encoding human NeuroD},
  author={Yong-Shik Yoon and T. Noma and Y. Yamashiro and H. Ito and A. Nakazawa},
  journal={Neuroscience Letters},
  • Yong-Shik Yoon, T. Noma, +2 authors A. Nakazawa
  • Published 1998
  • Biology, Medicine
  • Neuroscience Letters
  • NeuroD is a basic helix-loop-helix transcription factor that binds to an E-box sequence, CANNTG, in the target gene promoter region. The gene encoding NeuroD is expressed specifically in brain, intestine, and pancreatic cells and plays a pivotal role in tissue-specific differentiation. To investigate the regulation of human NeuroD gene expression, we isolated and sequenced a genomic DNA containing two exons and flanking regions of the NeuroD gene. The sizes of exons 1 and 2 were 168 and 2404 bp… CONTINUE READING
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