Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin.

@article{EspinoSols2008MolecularCA,
  title={Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin.},
  author={Gerardo Pavel Espino-Sol{\'i}s and Joel Osuna-Quintero and Lourival Domingos Possani},
  journal={Veterinary immunology and immunopathology},
  year={2008},
  volume={122 3-4},
  pages={326-34}
}
This work reports the cloning and sequence determination of the horse alpha subunit of the integrin CD11c/CD18, a marker of dendritic cells. A cDNA clone of 4582 base pairs was obtained. It encodes a protein segment of 1086 amino acid residues of the extracellular domain with 10 potential sites of glycosylation, a transmembrane domain of 32 residues and a C-terminal cytoplasmic tail of 24 residues. A phylogenetic analysis of this integrin shows close similarity (83%) with that of Canis… CONTINUE READING