Molecular cloning and characterization of sea bass (Dicentrarchus labrax, L.) MHC class I heavy chain and β2-microglobulin.

@article{Pinto2013MolecularCA,
  title={Molecular cloning and characterization of sea bass (Dicentrarchus labrax, L.) MHC class I heavy chain and β2-microglobulin.},
  author={Rute D Pinto and Elisa Randelli and Francesco Buonocore and Pedro Jos{\'e} Barbosa Pereira and Nuno M S dos Santos},
  journal={Developmental and comparative immunology},
  year={2013},
  volume={39 3},
  pages={234-54}
}
In this work, the gene and cDNA of sea bass (Dicentrarchus labrax) β2-microglobulin (Dila-β2m) and several cDNAs of MHC class I heavy chain (Dila-UA) were characterized. While Dila-β2m is single-copy, numerous Dila-UA transcripts were identified per individual with variability at the peptide-binding domain (PBD), but also with unexpected diversity from the connective peptide (CP) through the 3' untranslated region (UTR). Phylogenetic analysis segregates Dila-β2m and Dila-UA into each subfamily… CONTINUE READING

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