Molecular cloning and characterization of neutral ceramidase homologue from the red flour beetle, Tribolium castaneum.

@article{Zhou2011MolecularCA,
  title={Molecular cloning and characterization of neutral ceramidase homologue from the red flour beetle, Tribolium castaneum.},
  author={Ying Zhou and Xian-Wen Lin and Qiong Yang and Yan-Ru Zhang and Jing-qun Yuan and Xin-da Lin and Ruijuan Xu and Jiaan Cheng and Cungui Mao and Zeng-rong Zhu},
  journal={Biochimie},
  year={2011},
  volume={93 7},
  pages={1124-31}
}
Ceramidase plays an important role in regulating the metabolism of sphingolipids, such as ceramide, sphingosine (SPH), and sphingosine-1-phosphate (S1P), by controlling the hydrolysis of ceramide. Here we report the cloning and biochemical characterization of a neutral ceramidase from the red flour beetle Tribolium castaneum which is an important storage pest. The Tribolium castaneum neutral ceramidase (Tncer) is a protein of 696 amino acids. It shares a high degree of similarity in protein… CONTINUE READING

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