Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene.

@article{Aikawa1997MolecularCA,
  title={Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene.},
  author={Yoshikatsu Aikawa and Hiroshi H. Hara and Toshiki Watanabe},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={236 3},
  pages={559-64}
}
Null mutations in the retinal degeneration B gene (rdgB) in flies result in an activity-dependent retinal degeneration. Here we report the isolation of the mouse and human homologues of rdgB gene that are strongly expressed in brain and moderately expressed in other tissues. The deduced amino acid sequences encoding a 1244 a.a protein bear a 96% similarity between mouse and human and resemble the Drosophila rdgB, particularly in the phosphatidylinositol transfer domain at the N-terminus and in… CONTINUE READING
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