Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22.

  title={Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22.},
  author={Hiroyuki Kirikoshi and Noriyuki Sagara and Tetsuroh Saitoh and Kiyoshi Tanaka and Hisahiko Sekihara and Koichiro Shiokawa and Motonobu Katoh},
  journal={Biochemical and biophysical research communications},
  volume={274 2},
The fibroblast growth factors (FGFs) play important roles in morphogenesis, angiogenesis, tissue remodeling, and carcinogenesis. Human FGF-20 has been cloned and characterized in this study. FGF-20 encodes a 211-amino-acid polypeptide with the FGF-core domain. A strong hydrophobic region was found in the FGF-core domain of FGF-20; however, no typical N-terminal signal sequence was found in FGF-20, just as in FGF-9 and FGF-16. Total amino acid identities are as follows: FGF-20 vs FGF-9, 71.6… CONTINUE READING
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