Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin‐activating enzyme complex

@article{Gong1999MolecularCA,
  title={Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin‐activating enzyme complex},
  author={Limin Gong and B Q Li and Stephanos G Millas and Edward T.H. Yeh},
  journal={FEBS Letters},
  year={1999},
  volume={448}
}
Sentrin‐1/SUMO‐1 is a novel ubiquitin‐like protein, which can covalently modify a limited number of cellular proteins. Here we report the identification of the sentrin‐activating enzyme complex, which consists of two proteins AOS1 and UBA2. Human AOS1 is homologous to the N‐terminal half of E1, whereas human UBA2 is homologous to the C‐terminal half of E1. The human UBA2 gene is located on chromosome 19q12. Human UBA2 could form a β‐mercaptoethanol‐sensitive conjugate with members of the… Expand
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