Molecular cloning and characterization of Drosophila genes encoding small GTPases of the rab and rho families

@article{Sasamura1997MolecularCA,
  title={Molecular cloning and characterization of Drosophila genes encoding small GTPases of the rab and rho families},
  author={Takeshi Sasamura and Toshiyuki Kobayashi and Shoko Kojima and Hiroshi Qadota and Yoshikazu Ohya and I. Masai and Yasuo Hotta},
  journal={Molecular and General Genetics MGG},
  year={1997},
  volume={254},
  pages={486-494}
}
We have isolated eight genes from Drosophila, small GTPases. They can be classified into three rab family genes (Drab2, Drab5, Drab11) and five rho family genes (Drac1a, Drac1b, Drac3, Dcdc42, DrhoA). While Drac3 is a novel type of rac gene, others are homologues of known mammalian genes for small GTPases. Northern blot analyses showed that all the genes are expressed throughout all developmental stages from embryo to adult. In situ hybridization to embryos revealed that Drab2, Drac1b, and… CONTINUE READING