Molecular cloning and characterization of expressed human ecto-nucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) and its soluble extracellular domain.

@article{Knowles2006MolecularCA,
  title={Molecular cloning and characterization of expressed human ecto-nucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) and its soluble extracellular domain.},
  author={Aileen F. Knowles and Cheryl Shuang-wu Li},
  journal={Biochemistry},
  year={2006},
  volume={45 23},
  pages={7323-33}
}
An ecto-nucleoside triphosphate diphosphohydrolase (ecto-NTPDase) has been cloned from human liver RNA by RT-PCR. The 1.5 kb cDNA codes for a protein of 495 amino acids. Sequence analysis indicated that it is most closely related to a chicken ecto-ATPDase previously cloned in our laboratory [Knowles et al. (2002) Eur. J. Biochem. 269, 2373-2382] and a mouse homologue that has been designated as E-NTPDase 8 [Bigonnesses et al. (2004) Biochemistry 43, 5511-5519]. The human E-NTPDase 8 has similar… CONTINUE READING

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