Molecular cloning and characterization of an intracellular chloride channel in the proximal tubule cell line, LLC-PK1.

@article{Dowland2000MolecularCA,
  title={Molecular cloning and characterization of an intracellular chloride channel in the proximal tubule cell line, LLC-PK1.},
  author={L K Dowland and Valerie Ann Luyckx and Alissa H Enck and Baudouin Leclercq and Alan S L Yu},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 48},
  pages={37765-73}
}
CLC5 is an intracellular chloride channel of unknown function, expressed in the renal proximal tubule. The subcellular localization and function of CLC5 were investigated in the LLC-PK1 porcine proximal tubule cell line. We cloned a cDNA for the porcine CLC5 ortholog (pCLC5) that is predicted to encode an 83-kDa protein with 97% amino acid sequence identity to rat and human CLC5. By immunofluorescence, pCLC5 was localized to early endosomes of the apical membrane fluid-phase endocytotic pathway… CONTINUE READING
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