Molecular cloning and characterization of an insulin-regulatable glucose transporter

@article{James1989MolecularCA,
  title={Molecular cloning and characterization of an insulin-regulatable glucose transporter},
  author={D. James and M. Strube and Mike Muecdler},
  journal={Nature},
  year={1989},
  volume={338},
  pages={83-87}
}
  • D. James, M. Strube, Mike Muecdler
  • Published 1989
  • Biology, Medicine
  • Nature
  • A MAJOR mechanism by which insulin stimulates glucose transport in muscle and fat is the translocation of glucose transporters from an intracellular membrane pool to the cell surface1–5. The existence of a distinct insulin-regulatable glucose transporter was suggested by the poor cross-reactivity between antibodies specific for either the HepG2 or rat brain glucose transporters and the rat adipocyte glucose transporter6,7. More direct evidence was provided by the production of a monoclonal… CONTINUE READING
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