Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.

@article{Ma1993MolecularCA,
  title={Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.},
  author={D Ma and David N. Cook and Marie Hebert Alberti and N G Pon and Hiroshi Nikaido and J. E. Hearst},
  journal={Journal of bacteriology},
  year={1993},
  volume={175 19},
  pages={
          6299-313
        }
}
The DNA fragment containing the acrA locus of the Escherichia coli chromosome has been cloned by using a complementation test. The nucleotide sequence indicates the presence of two open reading frames (ORFs). Sequence analysis suggests that the first ORF encodes a 397-residue lipoprotein with a 24-amino-acid signal peptide at its N terminus. One inactive allele of acrA from strain N43 was shown to contain an IS2 element inserted into this ORF. Therefore, this ORF was designated acrA. The second… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 158 CITATIONS, ESTIMATED 57% COVERAGE

Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli.

  • Journal of bacteriology
  • 1996
VIEW 12 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The intrinsic resistome of bacterial pathogens

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Structure and mechanism of RND-type multidrug efflux pumps.

  • Advances in enzymology and related areas of molecular biology
  • 2011
VIEW 5 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1995
2019

CITATION STATISTICS

  • 14 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Locations of the envCD genes on the physical map of the Escherichia coli chromosome

Y. Kohara, K. Akiyama
  • J . Bacteriol
  • 1992

Lipoproteins in bacteria

C. F. Higgins
  • J . Bioenerg . Biomembr .
  • 1990

Molecular cloning of the envC gene of Escherichia coli

B. Henrich, R. Plapp
  • Curr . Microbiol .
  • 1990

Genetic analysis of mutations that compensate for loss of Escherichia coli DNA topoisomerase I

W. Miller, J. Ostell
  • J . Bacteriol .
  • 1985

Molecular basis of bacterial outer membrane permeability

P. Plesiat
  • Microb . Rev .
  • 1985