Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.

@article{Wang1996MolecularCA,
  title={Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.},
  author={Xiaohui Wang and Katrina Diener and D Jannuzzi and David B. Trollinger and Teresita Tan and Henri Lichenstein and Maciej Żukowski and Zemin Yao},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 49},
  pages={31607-11}
}
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. We report herein the isolation of a cDNA encoding a novel protein kinase designated MAPKKK5 from a human macrophage library. The nucleotide sequence predicts that MAPKKK5 encodes an open… CONTINUE READING

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