Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis.

@article{Inanobe1999MolecularCA,
  title={Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis.},
  author={Atsushi Inanobe and Yoshiyuki Horio and Akikazu Fujita and Masayuki Tanemoto and Hiroshi Hibino and Kiyoshi Inageda and Yoshihisa Kurachi},
  journal={The Journal of physiology},
  year={1999},
  volume={521 Pt 1},
  pages={19-30}
}
1. One of the features of weaver mutant mice is male infertility, which suggests that Kir3.2, a G-protein-gated inwardly rectifying K+ channel subunit, may be involved in spermatogenesis. Therefore, we have characterized the Kir3.2 isoform in mouse testis using immunological, molecular biological and electrophysiological techniques. 2. Testicular membrane contained a protein that was recognized by the antibody specific to the C-terminus of Kir3.2c (aG2C-3). Its molecular mass was approximately… CONTINUE READING