Molecular cloning and characterization of a novel gene upregulated early during postnatal rat lung development.

  title={Molecular cloning and characterization of a novel gene upregulated early during postnatal rat lung development.},
  author={L. Blomberg and W. Chan and L. Clerch and D. Massaro},
  journal={Biochimica et biophysica acta},
  volume={1574 3},
Alveoli form, in part, by subdivision (septation) of saccules constituting the gas exchange region of the immature lung. Rat lungs septate from postnatal day 4 through 14 but alveoli in male rats continue to form, by other means, until about age 44 days. In rats, we sought to identify genes involved in septation. Using differential display reverse transcription polymerase chain reaction, we cloned a cDNA, rA5D3, that had 1270 bp with an open reading frame encoding a putative polypeptide of 165… Expand
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