Molecular cloning and characterization of a cDNA encoding a laminin-binding protein (AhLBP) from Acanthamoeba healyi.

@article{Hong2004MolecularCA,
  title={Molecular cloning and characterization of a cDNA encoding a laminin-binding protein (AhLBP) from Acanthamoeba healyi.},
  author={Yeon-Chul Hong and Won-Myung Lee and Hyun-Hee Kong and Hae-Jin Jeong and D G Chung},
  journal={Experimental parasitology},
  year={2004},
  volume={106 3-4},
  pages={95-102}
}
Adherence of Acanthamoeba to host tissue is believed to be crucial in the establishment of amoebic keratitis or GAE. We have isolated a cDNA from a GAE-causing gymnoamoeba, Acanthamoeba healyi, encoding a protein that binds laminin by screening with a peptide G-specific DNA probe. The cDNA clone (AhLBP) was identified on the basis of sequence homology to the nonintegrin mammalian metastasis-associated 67-kDa laminin receptor (67-LR). The predicted amino acid sequence is 256 residues long with a… CONTINUE READING
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