Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase.

@article{Spicer1997MolecularCA,
  title={Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase.},
  author={Andrew P. Spicer and John S Olson and John Alan McDonald},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 14},
  pages={8957-61}
}
We report the isolation of a cDNA encoding the third putative hyaluronan synthase, HAS3. Partial cDNAs and genomic fragments of mouse Has3 were obtained using a degenerate polymerase chain reaction approach. Partial clones facilitated the isolation of genomic and cDNA clones representing the mouse Has3 open reading frame. The open reading frame of 554 amino acids predicted a protein of 63.3 kDa with multiple transmembrane domains and several consensus HA binding motifs. Sequence comparisons… CONTINUE READING

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