Molecular cloning and characterization of a cytochrome P450 taxoid 9á-hydroxylase in Ginkgo biloba cells.

  title={Molecular cloning and characterization of a cytochrome P450 taxoid 9{\'a}-hydroxylase in Ginkgo biloba cells.},
  author={Nan Zhang and Zhentai Han and Guiling Sun and Angela M Hoffman and I. W. Wilson and Yanfang Yang and Qian Gao and Jianqiang Wu and Dan Xie and Jungui Dai and Deyou Qiu},
  journal={Biochemical and biophysical research communications},
  volume={443 3},
Taxol is a well-known effective anticancer compound. Due to the inability to synthesize sufficient quantities of taxol to satisfy commercial demand, a biotechnological approach for a large-scale cell or cell-free system for its production is highly desirable. Several important genes in taxol biosynthesis are currently still unknown and have been shown to be difficult to isolate directly from Taxus, including the gene encoding taxoid 9α-hydroxylase. Ginkgo biloba suspension cells exhibit taxoid… CONTINUE READING


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