Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis.

@article{Feng2001MolecularCA,
  title={Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis.},
  author={Brian Feng and Xiaoting Wang and M. Hauser and Stefanie Kaufmann and Stephan Jentsch and Gerhard Haase and Jeffrey M. Becker and Paul J. Szaniszlo},
  journal={Infection and immunity},
  year={2001},
  volume={69 3},
  pages={1781-94}
}
1,8-Dihydroxynaphthalene (1,8-DHN) is a fungal polyketide that contributes to virulence when polymerized to 1,8-DHN melanin in the cell walls of Wangiella dermatitidis, an agent of phaeohyphomycosis in humans. To begin a genetic analysis of the initial synthetic steps leading to 1,8-DHN melanin biosynthesis, a 772-bp PCR product was amplified from genomic DNA using primers based on conserved regions of fungal polyketide synthases (Pks) known to produce the first cyclized 1,8-DHN-melanin pathway… CONTINUE READING

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