Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-I.

@article{Yamana2001MolecularCA,
  title={Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-I.},
  author={Kei Yamana and Hiroshi Wada and Yutaka Takahashi and Hiroko Sato and Yoshiko Kasahara and Mamoru Kiyoki},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={280 4},
  pages={1101-6}
}
Chondromodulin-I (ChM-I) is a cartilage-specific glycoprotein that stimulates the growth of chondrocytes and inhibits the tube formation of endothelial cells. In the present study, we identified a novel ChM-I like molecule, designated ChM1L. Cloning of full length cDNAs of human, mouse, and rat ChM1L revealed that ChM1L encodes 317 amino acids novel type II transmembrane protein. ChM1L protein was expressed on the cell surface as N-glycosylated and non-N-glycosylated protein with molecular mass… CONTINUE READING