Molecular cloning and characterisation of a fish PKR-like gene from cultured CAB cells induced by UV-inactivated virus.

@article{Hu2004MolecularCA,
  title={Molecular cloning and characterisation of a fish PKR-like gene from cultured CAB cells induced by UV-inactivated virus.},
  author={Cheng-yu Hu and Yibing Zhang and Guo-ping Huang and Qi-ya Zhang and Jian-Fang Gui},
  journal={Fish & shellfish immunology},
  year={2004},
  volume={17 4},
  pages={353-66}
}
The double-stranded-RNA-dependent protein kinase (PKR) is an important component in an antiviral defence pathway that is mediated by interferon (IFN) in vertebrates. Previously, some important IFN system genes had been identified from an IFN-producing CAB (crucian carp Carassius auratus blastulae embryonic) cells after treatment with UV-inactivated GCHV (grass carp haemorrhage virus). Here, a fish PKR-like gene, named CaPKR-like, is cloned and sequenced from the same virally infected CAB cells… CONTINUE READING

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