Molecular cloning, in vitro expression and bioactivity of dog A proliferation-inducing ligand (APRIL).

@article{Wang2009MolecularCI,
  title={Molecular cloning, in vitro expression and bioactivity of dog A proliferation-inducing ligand (APRIL).},
  author={Shu-Le Wang and Yu-Feng Cai and Qing-Ping Lin and Xiao-Ling Sheng and Yan Bin Shui and Shuang-quan Zhang},
  journal={Veterinary immunology and immunopathology},
  year={2009},
  volume={128 4},
  pages={
          407-12
        }
}
A proliferation-inducing ligand (APRIL) is a novel member of the tumor necrosis factor (TNF) family, which is involved in immune regulation. In this study, the cDNA of dog APRIL (dAPRIL) was amplified from dog spleen by RT-PCR. The open reading frame (ORF) of dAPRIL encodes a protein of 250-amino acid, containing a predicted transmembrane domain and a putative furin protease cleavage site like other mammalian APRILs. The amino acid identities between biologically soluble dAPRIL and its pig… CONTINUE READING
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