Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
@article{Stckli1989MolecularCE, title={Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor}, author={Kurt A. St{\"o}ckli and Friedrich Lottspeich and Michael Sendtner and Piotr Masiakowski and Patrick Carroll and Rudolf Götz and D. B. Lindholm and Hans Thoenen}, journal={Nature}, year={1989}, volume={342}, pages={920-923} }
CILIARY neurotrophic factor (CNTF) was originally characterized as a survival factor for chick ciliary neurons in vitro1. More recently, it was shown to promote the survival of a variety of other neuronal cell types2,3 and to affect the differentiation of E7 chick sympathetic neurons by inhibiting their proliferation and by inducing the expression of vasoactive intestinal peptide immunoreac-tivity (VIP-IR) 4. In cultures of dissociated sympathetic neurons from newborn rats, CNTF induces…
619 Citations
Differentiation of cholinergic neurons and physiological role of ciliary neurotrophic factor (CNTF)
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Ciliary neurotrophic factor inhibits differentiation of photoreceptor-like cells in rat pineal glands in vitro.
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Constitutive expression of ciliary neurotrophic factor in mouse hypothalamus
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In normal adult mice the ependyma of the third ventricle is both a source of and a target for CNTF, which may play hitherto unknown roles in hypothalamic function in physiological conditions.
Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival
- BiologyJournal of Cell Science
- 1991
Summary We have demonstrated that the extensive degeneration of motoneurons in the rat facial nucleus after transection of the facial nerve in newborn rats can be prevented by local ciliary…
Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
- BiologyThe Journal of cell biology
- 1991
It is demonstrated that the time course of the expression ofCNTF-mRNA and protein in the rat optic nerve is compatible with such a glial differentiation function of CNTF in vivo, and it is shown that the type 2 astrocyte-inducing activity previously demonstrated in optic nerve extract can be precipitated by an antiserum against CNTF.
Preparation and a structure-function analysis of human ciliary neurotrophic factor
- BiologyNeuroscience Research
- 1995
Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration
- BiologyThe Journal of cell biology
- 1992
It is demonstrated that the CNTF mRNA and protein levels and the manner in which they are regulated are compatible with such a function in lesioned peripheral neurons in the adult peripheral nervous system.
Cloning and expression of human ciliary neurotrophic factor.
- BiologyEuropean journal of biochemistry
- 1991
The cloning of the entire genomic sequence encoding human CNTF and its primary structure is reported, providing a basis for understanding the role of CNTF in nervous system physiology and pathology.
Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures
- BiologyThe Journal of neuroscience : the official journal of the Society for Neuroscience
- 1991
Investigation of neurotrophic effects of CNTF toward three populations of rat hippocampal neurons shows an increase in the neurofilament content of hippocampal cultures prepared from embryonic day 18 (E18) rat brain, and CNTF increased high-affinity GABA uptake and glutamic acid decarboxylase activity.
References
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The effects of CNTF on ChAT and TH are not due to selective survival of cells that acquire cholinergic traits in vitro, but are rather due to the induction of cholinergy differentiation of noradrenergic sympathetic neurons.
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It is shown that the type-2-astrocyte-inducing protein is similar or identical to ciliary neutrotrophic factor (CNTF)8,9, which promotes the survival of some types of peripheral neurons in vitro8, including ciliary ganglion neurons8,10, which suggests that CNTF, in addition to its effect on neurons, may be responsible for triggering type-1 astrocytes differentiation in the developing CNS.
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An assay system based on microwell cultures of ciliary ganglionic neurons was used to demonstrate that a very rich source of trophic factor for them is the intraocular target tissues they innervate, and suggests that this soluble factor may be involved in the normal development of the ciliary Ganglion.
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Purified CNTF represents the first purified neuronotrophic factor which addresses parasympathetic cholinergic neurons and supports the 24‐h survival of cultured neurons from certain chick and rodent sensory and sympathetic ganglia.