Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8).

@article{Kumar2001MolecularCE,
  title={Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8).},
  author={V B Sameer Kumar and Kamlesh P Vyas and Mark W. Franko and Vineet Choudhary and C Buddhiraju and John Nikko S. Alvarez and J Eileen Morley},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2001},
  volume={79 1},
  pages={57-67}
}
Alzheimer's disease (AD) is associated with increased expression of amyloid precursor protein (APP) with a consequent deposition of amyloid beta peptide (Abeta) which forms characteristic senile plaques. We have noticed that the senescence accelerated mouse (SAMP8), a strain of mouse that exhibits age-dependent defects such as loss of memory and retention at an early age of 8-12 months, also produces increased amounts of APP and Abeta similar to those observed in Alzheimer's disease (AD). In… CONTINUE READING
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