Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

@article{Ruat1993MolecularCC,
  title={Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.},
  author={Martial Ruat and Elisabeth Traiffort and Rob Leurs and Jo{\"e}l Tardivel-Lacombe and J. D{\'i}az and J-M. Arrang and J-C. Schwartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 18},
  pages={
          8547-51
        }
}
  • M. RuatE. Traiffort J. Schwartz
  • Published 15 September 1993
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
By using a strategy based on nucleotide sequence homology, we have cloned a cDNA encoding a functional serotonin (5-HT) receptor. The deduced amino acid sequence of the 5-HT7 receptor displays limited homology with that of other 5-HT receptors. In addition to the seven stretches of hydrophobic amino acids that characterize the superfamily of receptors interacting with guanine nucleotide-binding proteins, the 448-aa sequence of the 5-HT7 receptor contains a hydrophobic domain located at its N… 

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