Molecular clock of silent substitution: At least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes

@article{Miyata1982MolecularCO,
  title={Molecular clock of silent substitution: At least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes},
  author={Takashi Miyata and Hidenori Hayashida and Reiko F. Kikuno and Masami Hasegawa and Midori Kobayashi and Katsuro Koike},
  journal={Journal of Molecular Evolution},
  year={1982},
  volume={19},
  pages={28-35}
}
For each of eleven different types of nuclear genes, comparisons of the protein coding sequences were made between human, mouse and rat pairwisely, and the evolutionary rate of silent substitution, v S nucl. , was estimated. It is shown that the v S nucl. is not only very high (=5.37×10−9/site/yr), but also approximately uniform for different genes regardless of the types, which confirms our previous results (Miyata et al. 1980b). This is in sharp contrast to the rate of protein evolution which… CONTINUE READING

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Thc structure of cytochromc e and the

  • RE Dickerson
  • 1971
Highly Influential
4 Excerpts

Evolutionary changes and functional constraint in DNA sequences

  • T Miyata
  • Kimuxa M (ed) Molecular Evolution,
  • 1982
1 Excerpt

The rapid rate of synonymous substitution in mtDNA genes

  • Brown
  • 1982

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