Molecular clock in neutral protein evolution

  title={Molecular clock in neutral protein evolution},
  author={Claus O. Wilke},
  journal={BMC Genetics},
  pages={25 - 25}
A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean) substantially larger than one. This observation has been termed the overdispersed molecular clock. On the basis of in silico protein-evolution experiments, Bastolla and coworkers recently proposed an explanation for this observation: Proteins drift in neutral space, and can temporarily get trapped in regions of substantially reduced neutrality. In… CONTINUE READING