Molecular classifiers for acute kidney transplant rejection in peripheral blood by whole genome gene expression profiling.

@article{Kurian2014MolecularCF,
  title={Molecular classifiers for acute kidney transplant rejection in peripheral blood by whole genome gene expression profiling.},
  author={Sunil M. Kurian and Ashley N Williams and Terri Gelbart and Donald D Campbell and Tony S Mondala and Steven Robert Head and Steve Horvath and Lillian Gaber and Richard F. Thompson and Thomas C. Whisenant and Wei Ju Lin and Peter Langfelder and Elizabeth H. Robison and Randolph L. Schaffer and Jonathan S. Fisher and John J Friedewald and Stuart M. Flechner and Larry Chan and Alexander C. Wiseman and Hamid Shidban and Robert Mendez and Raymond L. Heilman and Michael M I Abecassis and Christopher Lee Marsh and Daniel R. Salomon},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2014},
  volume={14 5},
  pages={1164-72}
}
There are no minimally invasive diagnostic metrics for acute kidney transplant rejection (AR), especially in the setting of the common confounding diagnosis, acute dysfunction with no rejection (ADNR). Thus, though kidney transplant biopsies remain the gold standard, they are invasive, have substantial risks, sampling error issues and significant costs and are not suitable for serial monitoring. Global gene expression profiles of 148 peripheral blood samples from transplant patients with… CONTINUE READING

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