Molecular classification of breast carcinomas using tissue microarrays.

  title={Molecular classification of breast carcinomas using tissue microarrays.},
  author={Grace M Callagy and Elena Cattaneo and Yataro Daigo and Lisa C. Happerfield and Lynda G. Bobrow and Paul D P Pharoah and Carlos Caldas},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  volume={12 1},
The histopathologic classification of breast cancer stratifies tumors based on tumor grade, stage, and type. Despite an overall correlation with survival, this classification is poorly predictive and tumors with identical grade and stage can have markedly contrasting outcomes. Recently, breast carcinomas have been classified by their gene expression profiles on frozen material. The validation of such a classification on formalin-fixed paraffin-embedded tumor archives linked to clinical… CONTINUE READING
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