Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy

@article{Andr2006MolecularCO,
  title={Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy},
  author={Fabrice Andr{\'e} and Lajos Pusztai},
  journal={Nature Clinical Practice Oncology},
  year={2006},
  volume={3},
  pages={621-632}
}
Adjuvant chemotherapy improves survival of patients with stage I–III breast cancer but it is being increasingly recognized that the benefit is not equal for all patients. Molecular characteristics of the cancer affect sensitivity to chemotherapy. In general, estrogen-receptor-negative disease is more sensitive to chemotherapy than estrogren-receptor-positive disease. Large-scale genomic analyses of breast cancer suggest that further molecular subsets may exist within the categories defined by… CONTINUE READING